How to Activate GPT-4.1’s Agent Mode?
Read time: 5 minutes
Good news for those with Alzheimer’s or Parkinson’s: AI just cracked a mystery that’s haunted medicine for decades. Could this be the beginning of the end for Alzheimer’s? Also, OpenAI is secretly building its own X-like social network…
What are on FIRE 🔥
IN PARTNERSHIP WITH BELAY
Accomplish More. Juggle Less.
When you love what you do, it can be easy to take on more — more tasks, more deadlines, more hours – but before you know it, you don’t have time to do what you loved in the beginning. Don’t just do more – do more of what you do best.
BELAY’s flexible staffing solutions leverage industry experience with AI systems to increase productivity without sacrificing quality. You can accomplish more and juggle less with our exceptional U.S.-based Virtual Assistants, Accounting Professionals, and Marketing Assistants. Learn how with our free ebook, Delegate to Elevate, and leave the more to BELAY.
AI INSIGHTS
Researchers have developed RibbonFold, a new AI tool that accurately predicts the structure of misfolded proteins – key to diseases like Alzheimer’s and Parkinson’s. These diseases currently have no effective treatment and RibbonFold could finally change that.
Problem It Solves
-
Neurodegenerative diseases like Alzheimer’s and Parkinson’s are linked to misfolded proteins called amyloids.
-
Amyloids form twisted fibrils that disrupt brain function.
-
Existing AI tools (e.g. AlphaFold) were built for globular proteins and struggle with misfolded structures.
Breakthrough AI Tool: RibbonFold
-
A new AI-powered computational tool called RibbonFold.
-
Target the most disease-relevant fibril forms more accurately – abnormal protein structures found in Alzheimer’s and Parkinson’s disease.
-
Design drugs that bind specifically to harmful structures.
-
Outperforms AlphaFold and similar tools in this domain.
=> Finally, we know why diseases like Alzheimer’s show symptoms years after the misfolding begins. And AI just opens a new era in structural biology and neurodegeneration research.
Why It Matters: RibbonFold gives us a real shot at treatments that could change lives – not a guaranteed cure, but a huge step forward. It won’t erase these diseases overnight, but for the first time, it feels like we’re not just guessing. And maybe… that’s what hope really looks like.
PRESENTED BY HUBSPOT
Grow Your Business with HubSpot’s Free CRM
HubSpot offers an intuitive customer relationship management platform tailored for small businesses. Manage leads, track sales performance, and understand your customers with ease. Best of all, it’s completely free, with no limits on users or data, allowing you to store and manage up to 1,000,000 contacts.
TODAY IN AI
AI HIGHLIGHTS
📷 Google’s Veo 2 is now in the Gemini API, Google AI Studio and rolling out to Gemini Advanced users to create 8s, in 720p cinematic quality, with just one text prompt in Gemini App.
👥 OpenAI Sam Altman is secretly building its own X-like social network, ready to up his rivalry with Elon Musk and Mark Zuckerberg?
🎬 Kling AI in 2.0 era is opening a new chapter for the film industry, surprising 20M users by combining images into cohesive videos. It’s genuinely impressive artistically compared to Google’s Veo 2.
🧠 GPT-4.1 now acts more like a real agent if you prompt it right. To activate this agent mode, just add 3 simple reminders to your system prompt: Persistence, Tool-Calling, and Planning. You can also check example prompts here.
⚙️ Make.com AI Agents are just dropped when n8n’s blowing up. It’s their move to prove they’re not getting left behind and stay in the game.
🚫 The U.S. is restricting Nvidia’s AI chip sales to China, which could cost them up to $5.5 billion. Nvidia plans to boost U.S. investments, including building supercomputer factories in Texas.
💰 AI Daily Fundraising: Virtue AI just raised $30M to secure AI systems. Their platform helps stop issues like hallucinations and prompt attacks – used by companies like Uber, Glean, and teams in finance and healthcare.
AI SOURCES FROM AI FIRE
NEW EMPOWERED AI TOOLS
-
📌 n8nChat lets you build automations by describing them in plain language.
-
⚙️ Grok Studio 1st Version adds code execution and Google Drive support.
-
📚 Claude Research feature explores multiple angles of your question, conducting searches and delivering answers in minutes.
-
🎬 Pippit turns any website into multiple videos in just a few clicks.
-
🎯 Notion Mail uses AI to wrangle your messy inbox, and it rules.
AI QUICK HITS
-
🔥 OpenAI team is on fire executing insanely yet some stuff is still messy.
-
🐶 A new trend turning dogs into humans is blowing up on TikTok, Reddit, and X.
-
📚 ChatGPT’s new image library to view and edit all their AI-generated images.
-
🧸 Artists call AI “an insult to life itself” & are against AI dolls box trend.
-
😴 Some AI agents have learned to sleep so they can learn better.
AI CHART
Google’s AI Overviews and gen AI like ChatGPT are rapidly reshaping B2B tech buying. 90% of buyers click through to sources featured in AI overviews, reducing clicks to seller sites. This disrupts traffic patterns, especially for top-of-funnel queries.
AI Use in the Buying Journey Is Rising
-
In 2025, 40% of buyers say AI makes research easier – 2X increase YoY. 62% of them always or often fact-check AI outputs.
-
Gen Z = AI-native buyers. But “I trust the info, but I won’t rely only on it”.
-
Old metrics like traffic volume don’t matter as much anymore.
-
Instead, sellers need to focus on: impressions, trust signals and being everywhere buyers look: AI Overviews, LLMs, social, review sites.
So it’s still a huge SEO opportunity for visibility. The era of volume traffic is over… but higher-quality traffic is coming.
One more note for you here is AI can’t access gated content. So let’s save gated assets for high-intent buyers and provide late-funnel info (pricing, use cases) freely. Nobody wants to fill out a form just to read your PDF anymore.
Human Trust > AI Trust. Buyers still value peer feedback more than AI-generated content. AI forces us to be more human than ever.
AI JOBS
We read your emails, comments, and poll replies daily
How would you rate today’s newsletter?Your feedback helps us create the best newsletter possible
|
Hit reply and say Hello – we’d love to hear from you!
Like what you’re reading? Forward it to friends, and they can sign up here.
Cheers,
The AI Fire Team
Leave a Reply